|
|
isovaleryl-CoA + malonyl-CoA + H+ <=> phloroisovalerophenone + CO2 + CoA
|
2.3.1.156
phloroisovalerophenone synthase
2.3.1.220
2,4,6-trihydroxybenzophenone synthase
|
–
–
|
M
|
|
BRENDA:
BR29473
KEGG:
R05331
MetaCyc:
2.3.1.156-RXN
|
|
|
|
S-adenosyl-L-methionine + isovaleryl-CoA <=> CoA + S-methyl-5''-thioadenosine + N-isovaleryl-L-homoserine_lactone + H+
|
2.3.1.228
isovaleryl-homoserine lactone synthase
|
–
|
|
|
BRENDA:
BR50758
KEGG:
R10526
MetaCyc:
RXN-14718
|
|
|
|
4-methyl-2-oxopentanoate + CoA + NAD+ <=> isovaleryl-CoA + CO2 + NADH
|
1.2.1.25
branched-chain alpha-keto acid dehydrogenase system
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
–
|
M
|
|
BRENDA:
BS231865
KEGG:
R01651
MetaCyc:
2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN
SABIO-RK:
1788
|
|
|
|
4-methyl-2-oxopentanoate + CoA + oxidized_ferredoxin <=> isovaleryl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.2.7.7
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
1.2.7.8
indolepyruvate ferredoxin oxidoreductase
|
–
–
|
BMK
|
|
BRENDA:
BS359415
KEGG:
R08566
MetaCyc:
RXN-19534
|
|
|
|
isovaleryl-CoA + H2O <=> Isovalerate + CoA + H+
|
3.1.2.20
acyl-CoA hydrolase
|
–
|
M
|
|
BRENDA:
BS401203
MetaCyc:
RXN-21794
|
|
|
|
ATP + Isovalerate + CoA <=> diphosphate + AMP + isovaleryl-CoA
|
6.2.1.1
acetate---CoA ligase
6.2.1.44
3-(methylthio)propionyl---CoA ligase
|
–
–
|
M
|
|
BRENDA:
BS428220
MetaCyc:
RXN-18446
|
|
|
|
2,2-dimethylpropanoyl-CoA <=> isovaleryl-CoA
|
5.4.99.13
isobutyryl-CoA mutase
|
–
|
|
|
BRENDA:
BS445573
MetaCyc:
RXN-18585
SABIO-RK:
14743
|
|
|
|
isovaleryl-CoA + flavin <=> 3-methylcrotonoyl-CoA + reduced_flavodoxin
|
1.3.8.4
isovaleryl-CoA dehydrogenase
|
–
|
|
|
BRENDA:
BR36848
KEGG:
R04096
|
|
|
|
isovaleryl-CoA + FAD <=> 3-methylcrotonoyl-CoA + FADH2
|
1.3.8.4
isovaleryl-CoA dehydrogenase
1.3.8.7
medium-chain acyl-CoA dehydrogenase
|
–
–
|
BK
|
|
BRENDA:
BS424839
KEGG:
R04095
SABIO-RK:
3822
|
|
|
|
isovaleryl-CoA + glycine <=> CoA + N-isovalerylglycine
|
2.3.1.13
glycine N-acyltransferase
2.3.1.71
glycine N-benzoyltransferase
|
–
–
|
|
|
BRENDA:
BS320422
SABIO-RK:
12952
|
|
|
|
Isovalerate + acetoacetyl-CoA <=> isovaleryl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358835
SABIO-RK:
11115
|
|
|
|
isovaleryl-CoA + dihydrolipoamide <=> CoA + S-isovaleryldihydrolipoamide
|
2.3.1.168
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
|
–
|
|
|
BRENDA:
BS359558
SABIO-RK:
3824
|
|
|
|
isovaleryl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(3-methylbutanoyl)dihydrolipoyllysine
|
2.3.1.168
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
|
–
|
K
|
|
KEGG:
R04097
|
|
|
|
isovaleryl-CoA <=> Branched_chain_fatty_acid
|
not assigned
|
–
|
K
|
|
KEGG:
R04098
|
|
|
|
isovaleryl-CoA + [apo_BCAA_dehydrogenase_E2_protein]_N6-dihydrolipoyl-L-lysine <=> [apo_BCAA_dehydrogenase_E2_protein]_N6-S-[3-methylbutanoyl]dihydrolipoyl-L-lysine + CoA
|
2.3.1.168
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
|
–
|
|
|
MetaCyc:
ISOVALERYLCOA-DHLIPOAMIDE-RXN
|
|
|
|
3-acetylneosolaniol + isovaleryl-CoA <=> 3-acetyl_T-2_toxin + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN-17041
|
|
|
|
isovaleryl-CoA + malonyl-[acyl-carrier_protein] + H+ <=> 5-methyl-3-oxohexanoyl-[acp] + CoA + CO2
|
2.3.1.dr
|
–
|
M
|
|
MetaCyc:
RXN-21610
|
|
|
|
isovaleryl-CoA + malonyl-CoA + H+ <=> 4-hydroxy-6-isobutyl-2-pyrone + CoA + CO2
|
2.3.1
|
–
|
|
|
MetaCyc:
RXN-7825
|
|
|
|
isovaleryl-CoA + malonyl-CoA + H+ <=> 4-hydroxy-6-(4'-methyl-2'-oxopentyl)-2-pyrone + CoA + CO2
|
2.3.1
|
–
|
|
|
MetaCyc:
RXN-7826
|
|
|
|
isovaleryl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> 3-methylcrotonoyl-CoA + reduced_flavodoxin
|
1.3.8.4
isovaleryl-CoA dehydrogenase
|
–
|
M
|
|
MetaCyc:
RXN0-2301
|
|
|
|
sucrose + isovaleryl-CoA <=> 4-(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-25
|
|
|
|
4-(3-methylbutanoyl)sucrose + isovaleryl-CoA <=> 3,4-di(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-30
|
|
|
|
3-(2-methylbutanoyl)-4-(3-methylbutanoyl)sucrose + isovaleryl-CoA <=> 3-(2-methylbutanoyl)-3,4-di(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-34
|
|
|
|
3-dodecanoyl-4-(3-methylbutanoyl)sucrose + isovaleryl-CoA <=> 3-dodecanoyl-3,4-di(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-35
|
|
|
|
3-isobutanoyl-4-(3-methylbutanoyl)sucrose + isovaleryl-CoA <=> 3-isobutanoyl-3,4-di(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-38
|
|
|
|
3-decanoyl-4-(3-methylbutanoyl)sucrose + isovaleryl-CoA <=> 3-decanoyl-3,4-di(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-39
|
|
|
|
4-(3-methylbutanoyl)sucrose + isovaleryl-CoA <=> 2,4-di(3-methylbutanoyl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-42
|
|
|
|
3-(2-methylbutanoyl)-3,4-di(3-methylbutanoyl)sucrose + isovaleryl-CoA <=> 3-(2-methylbutanoyl)-1,3,4-tri(isovaleryl)sucrose + CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN18C3-46
|
|
|
|
isovaleryl-CoA + L-arginine <=> N-[(4S)-4-amino-7-methyl-5-oxooctyl]guanidine + CO2 + CoA
|
2.3.1.47
8-amino-7-oxononanoate synthase
|
–
|
|
|
BRENDA:
BS455801
|
|
|
|
isovaleryl-CoA + phosphate <=> isopentanoyl_phosphate + CoA
|
2.3.1.19
phosphate butyryltransferase
|
–
|
|
|
BRENDA:
BS320618
|
|
|
|
isovaleryl-CoA + phosphate <=> CoA + isopentanoyl_phosphate
|
2.3.1.19
phosphate butyryltransferase
|
–
|
|
|
BRENDA:
BS455802
|
|
|
|
4-methyl-2-oxopentanoate + CoA + Oxidized_benzyl_viologen <=> isovaleryl-CoA + CO2 + reduced_benzyl_viologen
|
1.2.7.7
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
|
–
|
|
|
BRENDA:
BS359427
|
|
|
|
acetyl-CoA + Isovalerate <=> acetate + isovaleryl-CoA
|
2.8.3.1
propionate CoA-transferase
|
–
|
|
|
BRENDA:
BS436984
|
|
|
|
isovaleryl-CoA + [acyl-carrier_protein] <=> CoA + an_isovaleryl-[acyl_carrier_protein]
|
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
|
–
|
|
|
BRENDA:
BS455800
|
|
|
|
3-methylcrotonoyl-CoA + NADPH <=> isovaleryl-CoA + NADP+
|
1.3.1.8
acyl-CoA dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS258635
|
|
|
|
isovaleryl-CoA + pseudotropine <=> CoA + O-isovalerylpseudotropine
|
2.3.1.186
pseudotropine acyltransferase
|
–
|
|
|
BRENDA:
BS392295
|
|
|
|
isovaleryl-CoA + electron_transfer_protein <=> 3-methylcrotonoyl-CoA + reduced_electron_transfer_protein
|
1.3.8.4
isovaleryl-CoA dehydrogenase
|
–
|
|
|
BRENDA:
BS371000
|
|
|
|
isovaleryl-CoA + 13-hydroxylupanine <=> CoA + 13-(3-methylbutyryl)oxylupanine
|
2.3.1.93
13-hydroxylupanine O-tigloyltransferase
|
–
|
|
|
BRENDA:
BS321492
|
|
|
|
isovaleryl-CoA + malonyl-[acyl-carrier_protein] <=> 3-oxo-5-methyl-hexanoyl-[acyl-carrier_protein] + CoA + CO2
|
2.3.1.180
beta-ketoacyl-[acyl-carrier-protein] synthase III
|
–
|
|
|
BRENDA:
BS382077
|
|
|
|
isovalerylcarnitine + CoA <=> isovaleryl-CoA + carnitine
|
2.3.1.7
carnitine O-acetyltransferase
|
–
|
|
|
BRENDA:
BS321241
|
|
|
|
isovaleryl-CoA <=> 4-hydroxy-6-isobutyl-2-pyrone + 4-hydroxy-6-(4''-methyl-2''-oxopentyl)-2-pyrone + CoA + CO2 + H2O
|
2.3.1.233
1,3,6,8-tetrahydroxynaphthalene synthase
|
–
|
|
|
BRENDA:
BS430276
|
|
|
|
isovaleryl-CoA <=> pentanoyl-CoA
|
5.4.99.64
2-hydroxyisobutanoyl-CoA mutase
|
–
|
|
|
BRENDA:
BS439631
|
|
|
|
isovaleryl-CoA + malonyl-CoA <=> bisnoryangonin-type_and_p-coumaroyltriacetic_acid_lactone-type_pyrones + CoA + CO2
|
2.3.1.95
trihydroxystilbene synthase
|
–
|
|
|
BRENDA:
BS321510
|
|
|
|
isovaleryl-CoA + acceptor <=> 3-methylcrotonoyl-CoA + reduced_acceptor
|
1.3.8.4
isovaleryl-CoA dehydrogenase
|
–
|
|
|
BRENDA:
BS258761
|
|
|
|
ATP + Isovalerate + CoA <=> ADP + phosphate + isovaleryl-CoA
|
6.2.1.13
acetate---CoA ligase (ADP-forming)
6.2.1.B11
|
–
–
|
|
|
BRENDA:
BS169
|
|
|
|
isovaleryl-CoA + phenazine_methosulfate <=> 3-methylcrotonoyl-CoA + reduced_phenazine_methosulfate
|
1.3.8.4
isovaleryl-CoA dehydrogenase
|
–
|
|
|
BRENDA:
BS373504
|
|
|
|
ATP + Isovalerate <=> AMP + diphosphate + isovaleryl-CoA
|
6.2.1.2
medium-chain acyl-CoA ligase
|
–
|
|
|
BRENDA:
BS197
|
|